Manufacturing genomic medicines is cumbersome, but new techniques using donated cells are more scalable and could slash production costs by 95%, potentially facilitating broader adoption.1
Recent regulatory approvals have helped genomic medicines gain momentum. Sales of genomic medicines are forecast to increase at a 37% compound annual growth rate from 2024-2030.2
GNOM provides global exposure to emerging areas within the Health Care sector, at the intersection of science and technology.
1International Society for Cell and Gene Therapy, Feb 2019
2Evaluate Pharma, n.d., Technology Overviews of: Cell Therapy, Gene Therapy, Gene-Modified Cell Therapy, and Genome Editing, all accessed 6 Jun 2025.
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* The financial statements include the Fund’s disclosures required by Items 7 through 11 of Form N-CSR, which includes the financial statements, financial highlights, and other important information when applicable.
** The financial statements include the Fund’s disclosures required by Items 7 through 11 of Form N-CSR, which includes the financial statements, financial highlights, and other important information when applicable.
Return on Equity | -25.60% | |
Weighted Avg. Market Cap | 33,166 M | |
2024 | 2025 | |
Price-to-earnings | -13.71 | -17.02 |
Price-to-book value | 3.83 | 5.05 |
VERSUS | BETA |
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S&P 500 | 2.22 |
NASDAQ-100 | 1.14 |
MSCI EAFE | -1.08 |
MSCI Emg. Mkts | -0.33 |
Standard Deviation | 189.50% |
NAV | $37.97 | Daily Change | $1.15 | 3.12% |
Market Price | $37.94 | Daily Change | $1.18 | 3.21% |
Fund NAV | Market Price | Index | |
---|---|---|---|
1 Year | -19.42% | -19.17% | -19.00% |
3 Years | -11.72% | -11.61% | -11.25% |
5 Years | -13.62% | -13.59% | -13.20% |
Since Inception | -9.07% | -8.78% | -8.61% |
Net Assets (%) | Ticker | Name | SEDOL | Market Price ($) | Shares Held | Market Value ($) |
---|---|---|---|---|---|---|
6.58 | ALNY | ALNYLAM PHARMACE | B00FWN1 | 452.17 | 6,935 | 3,135,798.95 |
5.75 | CRSP | CRISPR THERAPEUTICS AG | BDHF4K6 | 62.94 | 43,537 | 2,740,218.78 |
4.80 | RNA | AVIDITY BIOSCIENCES INC | BMWHPY1 | 41.81 | 54,690 | 2,286,588.90 |
4.76 | ILMN | ILLUMINA INC | 2613990 | 103.03 | 22,004 | 2,267,072.12 |
4.54 | GH | GUARDANT HEALTH INC | BFXC911 | 58.80 | 36,761 | 2,161,546.80 |
4.26 | NTRA | NATERA INC | BYQRG48 | 179.86 | 11,293 | 2,031,158.98 |
4.15 | ARWR | ARROWHEAD PHARMA | BYQBFJ8 | 31.51 | 62,740 | 1,976,937.40 |
3.81 | QGEN | QIAGEN N.V. | BS2CPH1 | 45.74 | 39,643 | 1,813,270.82 |
3.75 | WGS | GENEDX HOLDINGS CORP | BR841G5 | 130.71 | 13,674 | 1,787,328.54 |
3.72 | TECH | BIO-TECHNE CORP | BSHZ3Q0 | 52.99 | 33,445 | 1,772,250.55 |
Holdings are subject to change. "Cash" denotes U.S. dollars.
Industry | Weight (%) | |
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Pharmaceuticals, Biotechnology & Life Sciences | 90.2 | |
Health Care Equipment & Services | 9.8 |
Source: AltaVista Research, LLC
All Sector, Industry and Geographic breakdowns, where provided, are based on equity positions held by the ETF and exclude cash, currencies, and other holdings.